Generic Name: Ondansetron
Volume: 2ml and 4ml
Therapeutic category: Anti Emetics
Description: ETRON I.M./Slow I.V. Injection is a clear colorless solution. It contains 2mg/ml of Ondansetron Hydrochloride and it belongs to a group of medicines called Anti-emetics.
How ETRON works?
Ondansetron is a potent, highly selective 5HT3 receptor-antagonist. Its mode of action in the control of nausea and vomiting is not known. Chemotherapeutic agents and radiotherapy may cause release of 5HT in the small intestine initiating a vomiting reflex by activating vagal afferents via 5HT3 receptors. Ondansetron blocks the initiation of this reflex.
ETRON is indicated for the prevention and treatment of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, and for the prevention and treatment of post-operative nausea and vomiting.
Dosage and administration:
Chemotherapy and radiotherapy induced nausea and vomiting
The recommended I.V. or I.M. dose is 8 mg given as a slow injection immediately before treatment. Oral or rectal treatment is recommended to protect against delayed or prolonged emesis after the first 24 h.
Emetogenic chemotherapy and radiotherapy
The recommended I.V. dose is 8 mg given as a slow injection (in not less than 30 seconds) or as an infusion over 15 minutes immediately before treatment, followed by treatment with dosage forms other than I.V.
Alternatively, a dose of 8 mg may be given by slow I.V. or I.M. injection immediately before chemotherapy, followed by two further I.V. or I.M. doses of 8 mg 2 to 4 h apart, or by a constant infusion of 1 mg/h for up to 24 h. The efficacy of ETRON in highly emetogenic chemotherapy may be enhanced by the addition of a single I.V. dose of dexamethasone sodium phosphate, 20 mg administered prior to chemotherapy.
Body Surface Area based dose for children and adolescents (aged 6 months to 17 years)
|BSA||Day 1 (a,b)||Day 2 – 6 (b)|
|< 0.6 m2||5 mg/m2 i.v. plus 2 mg ondansetron syrup after 12 hrs||2 mg syrup every 12 hrs|
|≥ 0.6 m2||5 mg/m2 i.v. plus 4 mg ondansetron syrup or tablet after 12 hrs||4 mg syrup or tablet every 12 hrs|
a: The intravenous dose must not exceed 8mg.
b: The total daily dose must not exceed adult dose of 32 mg.
Alternatively, in children aged 6 months or older, ondansetron is administered as a single I.V. dose of 0.15 mg/kg (not to exceed 8 mg) immediately before chemotherapy. This dose may be repeated every four hours for a total of three doses. 4 mg orally twice daily can be continued for up to five days after a course of treatment. Adult doses must not be exceeded.
Prevention of Post-operative Nausea and Vomiting (PONV)
Adults: A single dose of 4 mg given by I.M. or slow I.V. at induction of anesthesia.
Children and Adolescents (aged 1 month to 17 years): ETRON can be given by slow I.V. injection at a dose of 0.1 mg/kg up to a maximum of 4 mg either prior to, at or after induction of anesthesia, or after surgery.
Patients with hepatic impairment: In such patients a total daily dose of 8 mg should not be exceeded.
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