Granset
Generic Name: Granisetron Hydrochloride
Strength: 1.0mg/ml
Volume: 1ml
Therapeutic category: Anti Emetics
GRANSET I.V./I.M. Injection is clear, colourless sterile solution. It contains 1.0 mg/ml of Granisetron Hydrochloride and it belongs to a group of medications called 5-HT, receptor antagonists. It works by blocking serotonin, a natural substance
in the body that causes nausea and vomiting.
HOW GRANSET WORKS?
Pharmacodynamics
Granisetron is a potent antiemetic and highly selective antagonist of 5-hydroxytryptamine 5-HT, receptors. Radio ligand binding studies have demonstrated that granisetron has negligible affinity for other receptor types including 5-HT,
alpha1 and alpha2, beta-adrenoreceptors, histamine H,, picrotoxin, benzodiazepine, opoid and dopamine Da binding sites.
Antagonism of 5-HT receptors located peripherally on agal nerve terminals and centrally in the chemoreceptor trigger zone in the area postrema, is one of the most effective pharmacological methods of preventing cytotoxic-induced emesis.
THERAPEUTIC INDICATION
- Prevention and treatment of nausea and vomiting in the body that causes nausea and vomiting induced by cytotoxic chemotherapy in adults and children.
- Prevention of nausea and vomiting induced by radiotherapy in adults only.
- Prevention and treatment of post-operative nausea and vomiting in adults only.
DOSAGE AND ADMINISTRATION
» Chemotherapy induced nausea and vomiting
• In adults:- A single dose of 3 mg of Granset should be administered as an intravenous infusion, diluted in 20 to 50 ml infusion fluid and administered over 5 minutes prior to the start of chemotherapy. The infusion should be
commenced within 30 minutes before the start of chemotherapy. For treatment of established
nausea and vomiting in adults, a single dose of 1 mg of Granset should be administered as a 5-
minute infusion. Further treatment doses of Granset may be administered if required at least 10 minutes apart. The maximum dose of Granset is 9 mg/24 hours.
• In Children: – The recommended intravenous dose of Granset in children is 20 ug to 40 ug/kg body weight (up to 3 mg), which should be administered as an intravenous infusion, diluted in 10 to 30 ml infusion fluid and administered over 5 minutes, no more than 30 minutes before the start of chemotherapy.
» Radiotherapy induced nausea and vomiting
Adults:
• For prevention of nausea and vomiting in adults, a single dose of 3 mg of Granset should be administered as an intravenous infusion, diluted in 20 to 50 ml infusion fluid and administered over 5 minutes prior to the start of radiotherapy.
» Post-operative nausea and vomiting
Adults:
Excretion
• In adults: A single dose of 1 mg of Granset should be administered as a 30 second intravenous injection prior to induction of
anaesthesia.
• Treatment of established post-operative nausea and vomiting in adults: A single dose of safely administered with benzodiazepines 1 mg of Granset should be administered by intravenous injection over 30 seconds. Patients undergoing anesthesia for elective surgery have received a total dose of 3 mg granisetron intravenous in one day.
Prescribing Information: PDF Download
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