Brand Name: Melcomid
Generic Name: Metoclopramide Hydrochloride
Strength: 5mg/ml
Volume: 2ml
Therapeutic category: Anti Emetics

Description: MECLOMID I.V./I.M. Injection is clear and colorless to almost colorless solution. It contains 5.0 mg/ml of Anhydrous Metoclopramide Hydrochloride and it belongs to a group of medicines called Antiemetic.

How MECLOMID works?

Metoclopramide stimulates activity of the upper gastro-intestinal tract and restores normal co-ordination and tone. Gastric emptying is accelerated and the resting tone of the gastroesophageal sphincter is increased. Metoclopramide is a dopamine-receptor antagonist with a direct anti-emetic effect on the medullary chemoreceptor trigger zone.

Therapeutic Indication:

Adult population

  • To prevent nausea and vomiting that may occur after surgery
  • To treat nausea and vomiting including nausea and vomiting which may occur with a migraine
  • To prevent nausea and vomiting caused by radiotherapy

Pediatric population (aged 1-18 years) if other treatment does not work or cannot be used:

  • To prevent delayed nausea and vomiting that may occur after chemotherapy
  • To treat nausea and vomiting that has occurred after surgery

Dosage and administration:

The solution can be administered as I.M. or I.V. I.V. doses should be administered as a slow bolus (at least over 3 minutes).

All indications (adult population)

  • For prevention of PONV a single dose of 10mg is recommended.
  • For the symptomatic treatment of nausea and vomiting, including acute migraine-induced nausea and vomiting and for the prevention of radiotherapy-induced nausea and vomiting (RINV): the recommended single dose is 10 mg, repeated up to three times daily.

The maximum recommended daily dose is 30 mg or 0.5mg/kg body weight.

All indications (pediatric patients aged 1-18 years)

The recommended dose is 0.1 to 0.15 mg/kg body weight, repeated up to three times daily by intravenous route. The maximum dose in 24 hours is 0.5 mg/kg body weight.

Dosing Table

Age Body Weight Dose Frequency
1 – 3 years 10-14 kg 1mg Up to 3 times daily
3 – 5 years 15-19 kg 2mg Up to 3 times daily
5 – 9 years 20-29 kg 2.5mg Up to 3 times daily
9 – 18 years 30-60 kg 5mg Up to 3 times daily
15 – 18 years Over 60 kg 10mg Up to 3 times daily

The maximum treatment duration is 48 hours for treatment of established postoperative nausea and vomiting & 5 days for prevention of delayed chemotherapy-induced nausea and vomiting.

Prescribing Information: PDF Download

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