Generic Name: Neostigmine Injection IP
Therapeutic category: Acteylcholinesterase Inhibitors
NEOMINE is a clear, colorless solution. It belongs to a group of medicines called cholinesterase inhibitors. It is used when muscles become abnormally tired and weak (myasthenia gravis).
HOW NEOMINE WORKS?
Neomine inhibits cholinesterase activity and prolongs and intensifies the muscarinic and nicotinic effects of acetylcholine. The anticholinesterase actions of NEOMINE are reversible. It is used mainly for its action on skeletal muscle and less frequently to increase the activity of smooth muscle.
Myasthenia Gravis, antagonist to non-depolarizing neuromuscular blockade, Paralytic ileus, Postoperative Urinary Retention, Paroxysmal Supraventricular Tachycardia.
Dosage and Administration
For the treatment of Myasthenia gravis, doses of 1 to 2.5mg may be given by I.M. or S.C. injection at intervals during the day when strength is most needed. The total daily dose is usually in the range of 5 to 20mg but higher doses may be required by some patients.
For the reversal of non-depolarizing neuromuscular blocking agents, the usual dose is 0.05 to 0.07mg per kg body weight, given concomitantly with or after atropine sulphate, by slow I.V. injection over an of 60 seconds. Additional neostigmine may be required to restore normal muscle power but a total of 5mg for adults and 2.5mg for children should not be exceeded. If preferred, the atropine sulphate may be administered prior to the neostigmine. For the management of post-operative distention, ileus and urinary retention the usual dose is 0.5 to 2.5 mg by S.C. or I.M. injection.
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