Brand Name: ESLOL
Strength: 10mg/ml
Volume: 10ml

Description: Eslol I.V. Injection is a clear colorless solution. It contains 10 mg/ml of Esmolo Hydrochloride and it belongs to a group of medicines called Beta blockers.

How ESLOL works:

  • Eslol works by controlling the rate and force of heartbeat and also helps to reduce blood pressure.
  • In human electrostudies, Eslol produced effects typical of a beta blocker: decrease in heart rate, increase in sinus cycle length, prolongation of the sinus node recovery time, prolongation of the AH interval during normal sinus rhythm and during atrial pacing.
  • In patients undergoing radionuclide angiography, it produced reactions in heart rate, systolic blood pressure, rate pressure product, left and right ventricular ejection fraction and cardiac index at rest, which were similar in magnitude to those produced by Propranolol.
  • During exercise, Eslol produced reductions in heart rate, rate pressure product and cardiac index which were also similar to those produced by propranolol, but produced a significantly larger fall in systolic blood pressure.

Therapeutic Indication:

  • Supraventricular Tachycardia (SVT)

Eslol is indicated for the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable.

Eslol is also indicated in no compensatory sinus tachycardia where, in the physician’s judgement, the rapid heart rate requires specific intervention.

  • Intraoperative and postoperative Tachycardia and/or Hypertension

Eslol is indicated for the treatment of tachycardia and hypertension that occur during induction and tracheal intubation during surgery, on emergence from anaesthesia, and in the postoperative period.

Dosage and Administration:

  • Supraventricular Tachycardia (SVT)

In SVT, responses to Eslol occur within the range of 0.05 to 0.2 mg/kg/min. The effective dosage is approximately 0.1 mg/kg/min although dosages as low as 0.025 mg/kg/min have been adequate in some patients.

To initiate treatment, administer a loading infusion of 0.5 mg/kg/min over 1 minute followed by a 4 minutes maintenance infusion of 0.05 mg/kg/min.

If an adequate therapeutic effect is observed over the 5 minutes of drug administration, maintain the maintenance infusion dosage with periodic adjustments up or down as needed.

If an adequate therapeutic effect is not observed, the same loading dose is repeated over one minute followed by an increased maintenance infusion rate of 0.1 mg/kg/min.

Continue titration procedure as above, repeating the original loading infusion of 0.5 mg/kg/min over 1 min, but increasing the maintenance infusion rate over the subsequent 4 minutes by 0.05 mg/kg/min increments.

As the desired heart rate or blood pressure is approached, omit subsequent loading doses and titrate the maintenance dosage up or down to endpoint.

  • Intraoperative and postoperative Tachycardia and/or Hypertension

In the intraoperative and postoperative settings, it is not always advisable to slowly titrate the dose of Eslol to a therapeutic effect. Therefore, two dosing options are presented:

Immediate control dosing and a gradual control when the physician has time to titrate.

Prescribing Information: PDF Download

The details of our product are included from the finalized insert available for our products.